Quintillion Quest features some twists to the regular incremental game formula:

It is not linear - there are many ways to beat the game.

Instead of prestiges there are separate runs, with permanent progress between the them.

There are roguelite elements, which add some randomness.

Each run can be failed halfway, if you fail to meet certain goals.

The game consists of exploring all the different options you have and choosing the best ones.

Having skill in the game is becoming familiar all its options and optimizing your runs.